The continuity of life and human settlement in the present-day municipality of Konjic spans 4,000 years. The abundance of water, forests, and wildlife attracted people, presumably as far back as the Paleolithic, while their life in the Neolithic period is evidenced by dwellings and artifacts found in Konjic itself, as well as in Donje Selo and Lisičići.
The Greek geographer Strabo left a record of the struggle between the Illyrian tribes of the Adriatae and Autariatae over a source of salt water (from 360 to 840 BC), and in addition, one of the main roads connecting Rome and Dalmatia with the Danube region passed through the territory of the present-day municipality of Konjic.

The Crkvine site near Lisičići is considered one of the most important Roman settlements in this area, where, among other things, archaeological remains of statues of the goddess Diana and the god Mithras were found. Above the railway station in Konjic, on the hill of Repovica, what are perhaps the most valuable archaeological remains in Konjic were discovered — a sanctuary of the sun god Mithras from the late 4th century.
A stone altar and a stone relief depicting the rituals of the Mithraic religious sect have been preserved. This relief, illustrating the cult of the god Mithras, is among the most precious exhibits of the National Museum in Sarajevo. As for the early Middle Ages, in Konjic this period was already marked by Slavs who lived in community with the Avars (Obri).